I'd play Sanders at home against the Indianapolis D in a game that is likely to be a shootout. The good news is that this is a choice between two good options
http://bpfantasy.weebly.com/ I'd definitely go Vincent Jackson. I love VJax and I'm not sold on Sanders yet, I want to see how he does first.
VJax. Disregard what they say, you play talent over match up. When has Peyton ever had a favorite receiver? he doesn't, that's why he is good. He has many mouths to feed and plus still building chemistry. I say VJax all day. Yeah bad match up, but how good is he? He can take the top off and will outplay boys. Hes a clear cut WR1, always start that over WR2-WR4 depending on the day
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Sanders. Better QB play and it's not clear yet if evens will cut in on his targets.
I'd definitely go Sanders. No Welker, so Sanders if even more valuable.
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Sanders is the second receiver of Peyton Manning! He's in for a good day.
Jackson is playing Carolina... You've found your answer.
Vincent is better obviously but he's got the tougher matchup, plus no Welker should open up Sanders for more targets.