No, you shouldn't unless someone gets hurt, you shouldn't let the first games influence your rankings of the players very much.

Go Charles or McCoy, Don't base it off of week 1 http://bpfantasy.weebly.com/

My league is just skipping week one and we are drafting tonight. So far Marshawn Lynch is doing better than both AP and McCoy. It just seems a little risky though. Also should I try for Peyton Manning? If not him should I go for Brees? Who should my first choices be for QB and RB